Abstract
The natural heptapeptide d-Ala-deltorphin II, the most selective agonist for δ-receptors currently available, was used to study the role of brain δ opioid receptors in the control of body temperature. In rats placed in a cold ambient temperature (4°C), intracerebroventricular injections of d-Ala-deltorphin II produced a significant hypothermia. In animals at an ambient temperature of 22°C, only the highest dose employed induced a slight fall in body temperature. At a warm temperature (34°C), d-Ala-deltorphin II induced no significant changes in body temperature. d-Ala-deltorphin II-induced hypothermia, unaffected by naloxone, was significantly reduced by the selective δ receptor antagonist naltrindole. These findings indicate that d-Ala-deltorphin II produces its hypothermic effects at a supraspinal δ receptor, and support the involvement of δ receptors in central control of body temperature.
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