Hypothermia renoprotection with self-made cold-saline-perfused capsule in the porcine model

Abstract

Objective To achieve hypothermia renoprotection in the laparoscopic partial nephrectomy with self-made cold-saline-perfused capsule in the porcine model.Methods Five domestic pigs underwent laparoscopic partial nephrectomy.After occlusion of the renal artery,the kidney was enveloped with cold-saline-perfused capsule to maintain hypothermia.Results After complete occlusion of the renal artery,a cold-saline (1-2℃)-perfused capsule enveloping the kidney was applied to decrease the temperature below 25.0℃ within 13 min and finally stabilize at 17-19 ℃.The core body temperature was maintained stable (fluctuation ＜ 1 ℃) within the procedure.No ischemic changes were noted on histologic review of the renal biopsy specimens.Conclusion Application of cold-saline-perfused capsule to the retroperitoneal laparoscopic partial nephrectomy in the porcine model effectively maintains hypothermia and protects renal function. Key words: Laparoscopic ; Partial nephrectomy; Hypothermia protection ; Cold-saline-perfused capsule