Abstract
Surv Anesthesiol 2016;60(2):73–74 This pilot study was undertaken to test the hypothesis that early and prolonged therapeutic hypothermia (TH; continued for a minimum of 72 hours, with rate of rewarming guided by intracranial pressure [ICP] and cerebral perfusion pressure [CPP]) would improve the outcome in children with traumatic brain injury (TBI). This multicenter trial, conducted in all 8 of the pediatric intensive care units (PICUs) in Australia and New Zealand and 1 in Canada, tested the protocol (including adherence, safety, and outcomes) in order to assess the feasibility of a phase III randomized controlled trial (RCT).
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