Abstract
The relationship between clinical thyroid disease and psychiatric symptoms and disorders is well established. The relationship between alterations of thyroid function and primary mood disorders is more complex. While various abnormalities of the thyroid axis have been identified, none is specific for depression and there is no clear evidence that thyroid hypofunction is a significant etiological factor in primary major depression. The literature on thyroid hormone treatment of depression, particularly triiodothyronine use in treatment-resistant major depression, is of interest and requires further investigation. Greater understanding about thyroid–brain relationships may yield important information about the biology of primary major mood disorders.
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