Abstract
One or more agents found in extracts of brains from estivating lungfish and hibernating ground squirrels depress oxygen consumption and colonic temperature when injected intravenously into mice. These observations from different laboratories confirm initial similar reports using rats as subjects. Comparison with rat brain extract injections indicate that the hypothermia was not solely a nonspecific response to foreign substance in the blood. Preliminary evidence suggests that the active agent(s) is a peptide with a molecular weight between 1000 and 1400 daltons.
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