Abstract
The possibility of using liposomes as intragastric carriers of insulin was investigated in normal and diabetic rats. 1·3 units of insulin entrapped in dipalmitoyl-phosphatidylcholine/cholesterol liposomes administered to normal rats decreased blood-glucose levels in 4 h to about 77% of those before treatment. Higher doses (4·2 and 8·4 units) extended this effect over 24 h. 1·0 units of insulin entrapped in the same liposomes had an even more pronounced effect in diabetic rats—levels of blood-glucose were reduced to 57% of pretreatment values after 4 h. Insulin entrapped in egg phosphatidylcholine/cholesterol liposomes was less effective. The effectiveness of liposome-entrapped insulin was similar in diabetic rats whether administered intragastrically or intraperitoneally but free insulin was more effective intraperitoneally. Radioimmunoassay of insulin in the serum confirmed that lowering of blood-glucose after the intragastric administration of liposome-entrapped insulin was related to the entry of at least some of the insulin into the circulation.
Published Version
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