Abstract
The effects of crude polysaccharide from Purslane (CPP) on body weight (bw), blood glucose, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), triglyceride (TG) and serum insulin levels were studied in diabetes mellitus mice. CPP treatment (200, 400 mg/kg bw) for 28 days resulted in a significant decrease in the concentrations of fasting blood glucose (FBG), TC and TG. Furthermore, CPP significantly increased the concentration of HDL-c, body weight and serum insulin level in the mice. In addition, according to acute toxicity studies and single cell gel electrophoresis analysis, CPP did not produce any physical or behavioral signs of toxicity. More significantly, our data demonstrated CPP exhibited the best effects at the dose of 400 mg/kg bw. The above results suggest that CPP can control blood glucose and modulate the metabolism of glucose and blood lipids in diabetes mellitus mice, so we conclude that CPP should be evaluated as a candidate for future studies on diabetes mellitus.
Highlights
Purslane (Little Hogweed; Chinese name: Ma-Chi-Xian) is a grassy plant with small yellow flowers and stems sometimes flushed red or purple, which grows widely in different areas of the world including the north of China [1,2]
The present results showed that the total cholesterol (TC) and TG levels were significantly elevated in the diabetic control group as compared to the normal control group (P < 0.05), and serum high-density lipoprotein cholesterol (HDL-c) level, a friendly lipoprotein, was decreased in diabetic control group as compared to the normal control group (P < 0.05)
Supplementation to the mice, there was a significant elevation in serum insulin level as compared to the diabetic control group ( p < 0.05), which implied that treatment with crude polysaccharide from Purslane (CPP) improved the insulin secretion on diabetic mice
Summary
Purslane (Little Hogweed; Chinese name: Ma-Chi-Xian) is a grassy plant with small yellow flowers and stems sometimes flushed red or purple, which grows widely in different areas of the world including the north of China [1,2]. Purslane is considered a type of common weed, but it can be eaten as a potherb without any side effects. China as a hypotensive and antidiabetic [5,6,7]. Though there is no scientific evidence to support the antidiabetic effects of Purslane, people continue to use it in the treatment of this condition. The objective of this study was to extract crude polysaccharide(s) from Purslane and assess the hypoglycemic effects of these constituents with animal tests for the use of this plant in the treatment of diabetes
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