Hypoglycemic Effect of Polyalthia longifolia on Glucose Tolerance in Glucose-Induced Hyperglycemic Mice and Analgesic Effect of Polyalthia longifolia in acetic acid-induced writhing model Mice

Abstract

The high level of blood glucose causes the diabetes and many of the diseases are concerned with the symptom of acute or chronic pain. The present study showed the hypoglycemic and analgesic effect of ethanolic extract of Polyalthia Longifolia leaf was investigated. Oral glucose tolerance test was performed in the present study to find the hypoglycemic effect and acetic acid-induced writhing method was used to test the analgesic effect of the leaves. The hypoglycemic effect was found from 16.25 mM to 6.22 mM SEM at the dose of 500 mg extract (p<0.05). The analgesic activity was observed 69.46 % and 58.08% at the rate of 500 mg and 250 mg (p<0.05) respectively compared to writhing inhibition of standard drug Diclofenac 78.16%. The presence of Alkaloid, Flavonoid, Gum, Tannin and Saponin in the extract of leaves may be the reason of these effects. Polyalthia Longifolia has much potential in the medicine of diabetic and pain.