Abstract
Substantial evidence suggests that phenolic extracts of Castanea mollissima spiny burs (CMPE) increase pancreatic cell viability after STZ (streptozotocin) treatment as a result of their antioxidant properties. In the present study, the hypoglycemic and hypolipidemic activities of CMPE were studied in normal and STZ-induced diabetic rats CMPE were orally administrated at doses of 150 and 300 mg/kg twice a day for 12 consecutive days. Serum glucose, triglyceride, total cholesterol, HDL- and LDL-cholesterol levels, malondialdehyde (MDA) level and SOD activity in liver, kidney, spleen and heart tissues were measured spectrophotometrically. In normal rats, no significant changes were observed in serum glucose, lipid profiles and tissue MDA and GSH levels after orally administration of CMPE. In diabetic rats, oral administration of CMPE at a dose of 300 mg/kg caused significant decreases in serum glucose, triglyceride, total cholesterol, LDL-cholesterol levels, as well as MDA and GSH levels in spleen and liver tissues. However, the 300 mg/kg dosage caused a significant body weight loss in both normal and diabetic rats. The observed effects indicated that CMPE could be further developed as a drug to prevent abnormal changes in blood glucose and lipid profile and to attenuate lipid peroxidation in liver and spleen tissues.
Highlights
Diabetes mellitus is one of the most common endocrine metabolic disorders, characterized by hyperglycemia due to defects in insulin secretion, action, or both
The results of this study showed that CMPE could reverse the hyperlipidemia in experimental diabetic rats, and may lead to a decrease in the risk of micro- and macrovascular disease and related complications [21]
The present study evaluated the hypoglycemic and hypolipidemic effects of polyphenol extracts of Castanea mollissima Blume spiny burs (CMPE) in normal and STZ induced diabetic rats
Summary
Diabetes mellitus is one of the most common endocrine metabolic disorders, characterized by hyperglycemia due to defects in insulin secretion, action, or both. Chronic hyperglycemia in diabetes is associated with long term damage, dysfunction and eventually the failure of organs, especially the kidneys, nerves, eyes and cardiovascular system, which has a significant impact on the health, quality of life, and expectancy of patients as well as on the health care system [1,2]. Several approaches are presently available to reduce the hyperglycemia including insulin therapy, and treatment with sulfonylureas, metaformin, and -glucosidase inhibitors, all of these therapies have limited efficacy and various side effects. Recently interest has focused on plant-based natural antioxidants such as tannins, polyphenols and flavonoids to reduce the negative effect of oxidative stress and free radicals in diabetes patients and to prevent the destruction of β-cells [6]
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