Hypoglycemic and hypolipidemic effect of Allopolyherbal formulations in streptozotocin induced diabetes mellitus in rats

Abstract

Aim of the studyIn the present study, we examined and compared the effect of Polyherbal (PH), Allopolyherbal-A (APH-A), Allopolyherbal-B (APH-B), and Allopolyherbal-C (APH-C) formulations on hyperglycemia, lipid profile, renal, and hepatic function in streptozotocin (STZ) induced diabetes mellitus in rats. Materials and methodsThe hypoglycemic activity (along with other parameters) of Polyherbal and Allopolyherbal formulations was investigated in STZ induced diabetes in rats. Polyherbal (PH) (3.63g/kgbodywt.); Allopolyherbal-A (APH-A) [(5mgGliclazide+1.81gPH)/kgbodywt.]; Allopolyherbal-B (APH-B) [(4mgGliclazide+2.17g of PH)/kgbodywt.]; Allopolyherbal-C (APH-C) [(2mg of Gliclazide+2.904g of PH)/kgbodywt.], and Gliclazide (10mg/kgbodywt.) were administered once a day, orally by gavages for 21days.Blood glucose levels were measured on 0, 7, 14, and 21days of the study; total cholesterol, triglycerides, LDL, VLDL, HDL, serum creatinine, SGOT, and SGPT were estimated on 21st day. ResultsGliclazide, Polyherbal (PH), Allopolyherbal-A (APH-A), Allopolyherbal-B (APH-B), and Allopolyherbal-C (APH-C) formulations treated rats showed significant (P<0.01) decrease in blood glucose, total cholesterol, triglycerides, LDL, VLDL, serum creatinine, SGOT, and SGPT level, along with significant increase in HDL. ConclusionsPresent findings provide experimental evidence that the combination of allopathic hypoglycemic drugs with hypoglycemic Polyherbal formulations provides effective and rapid glycemic control and can also minimize the cardiovascular risk factors of type II diabetes mellitus.