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Abstract
Recently, considerable attention has been focused on dietary supplements that possess hypoglycaemic and hypolipidemic properties in lieu of the synergistically synthesized drugs like statins and metiform which have been proven to have adverse effects. This present work was carried out to study the potential effects of Lipton tea aqueous extract (LTAE) on normal male albino rats. 36 six male Wistar rats weighing 115-150 g were assigned into four main groups; each group was divided into three subgroups, consisting of three replicates namely R1, R2 and R3 making a total of nine rats in each of the main groups. Group 1 served as the control and received only water, Group 2 received 200 mg/kg of LTAE, Group 3 received 400 mg/kg of the LTAE, while Group 4 received 800 mg/kg of LTAE. All treatment was given orally on daily basis for 28 consecutive days, but the parameters were assessed on weekly basis. The result revealed that, weight gain, fasting blood sugar and serum (total cholesterol, triglycerides, LDL-c and VLDL-c) significantly (p < 0.05) decrease in all the treated groups while HDL-c significantly (p < 0.05) increased when compared to the control group. The Lipton tea aqueous extract induced both a dose-dependent and a time-dependent effect in the parameters measured, apart from the total cholesterol which did not show a dose-dependent effect. This led to an overall decrease in the antherogenic index and coronary risk index, suggesting that LTAE possesses hypoglycaemic and hypoglycaemic activities in normal male rats.
Highlights
Diabetes mellitus (DM) is the term used to refer to impairment in insulin metabolism (Aizaki et al, 1999)
The result of the effect of Lipton tea aqueous extract (LTAE) on body weight gain showed that all treatments significantly (p < 0.05) precipitated dose-dependent decrease and time-dependent increase in body weight gain of the treated rats from week 1 to week 4 when compared to the control (Fig. 1)
The result of the effect of LTAE on fasting blood sugar level of normal albino rats showed that the extract significantly (p < 0.05) decreased the fasting blood sugar of the treated rats in both time dependent and dose dependent manner
Summary
Diabetes mellitus (DM) is the term used to refer to impairment in insulin metabolism (Aizaki et al, 1999). There are several forms of diabetes mellitus but of all the forms, type 1 and type 2 are the major forms of diabetes mellitus and is the leading cause of abnormalities in the metabolism of carbohydrates and lipids in the body (Allain et al, 1974; Eyo et al, 2011). Lipid and carbohydrates are important metabolites in the body and abnormalities in their metabolism can lead to development and progression of many diseases and eventually mortality if not properly treated (Al Jamal, 2014). The abnormality in the regulation of these metabolites in the body leads to increase in their amount in the body, a condition referred to as hyperglycaemia and hyperlipidemia, leading to multifarious group of chronic disorders and morbidity in the body (Willett et al, 2002; Abe et al, 2005). Ahmed (2005) opined that several chronic diseases have been associated with an increased level of glucose and lipid in the body
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