Effect of serum adropin level and cinnamon water extract on normal and alloxan-induced diabetic adult male albino rats

Abstract

Background: Adropin is a peptide first identified in 2008 in liver and brain tissues. It serves to modulate lipid and glucose metabolism and to maintain insulin sensitivity. It was found to be decreased in many disorders including diabetes mellitus (DM), atherosclerosis, diabetic nephropathy and many other diseases. Cinnamon tends to improve the serum glucose and lipid levels in diabetic subjects which may help in controlling DM and its disabling complications. Objective: To study the effect of serum adropin levels and cinnamon water extract on normal and alloxan-induced diabetic adult male albino rats. Materials and methods: Twenty-eight adult male albino rats of a local strain were used as an animal model for this study. They were divided into 4 equal groups; group 1 (control), group 2 (non-diabetic cinnamon-treated), group 3 (diabetic non treated), and group 4 (diabetic cinnamon-treated). After 4 weeks, blood samples were collected and serum was separated for the measurement of adropin level (by ELISA). Fasting blood sugar (FBS), HbA1C, cholesterol, LDL, HDL and TAGs were also measured. Collected Data were analyzed using SPSS version 25 and the difference between studied groups was considered significant when P ≤ 0.05. Results: This study showed that there was a significant increase in serum adropin level in alloxan induced diabetic rats when compared with the normal rats. Also, the increase in serum adropin level showed a significant positive correlation with HbA1C, cholesterol, LDL and TAGs and a significant negative correlation with HDL. On the other hand, treatment with cinnamon showed a significant improvement of FBS, HbA1C and lipid profile and this was associated with reduction in serum adropin level. Conclusion: The increase in serum adropin level in alloxan-induced diabetes is compensatory as it increases insulin sensitivity and ameliorates diabetic associated metabolic derangements and, in the future, it may be one of the members of diabetic medications.