Abstract
The major peach allergen Pru p 3 is responsible for allergies occurring mainly in the Mediterranean area. Hypoallergenic derivatives of Pru p 3 are disclosed which can be used as a vaccine in the treatment of allergic patients.
Highlights
IgE-mediated allergy to peach represents a frequent cause of severe anaphylactic reactions in Mediterranean countries
Hypoallergenic Pru p 3 derivatives have been constructed in order to minimize side-effects, but these molecules were not immunogenic in animal models
Two recombinant Pru p 3-derivatives were developed based on the Pru p 3 amino acid sequence, by introduction of point mutations, or rearrangements of Pru p 3 fragments and oligomerization
Summary
IgE-mediated allergy to peach represents a frequent cause of severe anaphylactic reactions in Mediterranean countries. Pru p 3, a nonspecific lipid transfer protein (LTP) from peach, was identified as an important elicitor of IgEmediated food hypersensitivity reactions to peach. Specific immunotherapy is currently the only allergen-specific and disease-modifying treatment of allergies, but has so far not been applied to food allergic patients due to the high risk of IgE-mediated side effects. Hypoallergenic Pru p 3 derivatives have been constructed in order to minimize side-effects, but these molecules were not immunogenic in animal models
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