Hyperuricemia as a Associated Factor to Atrial Fibrillation in Type 2 Diabetes Mellitus Patients an a Private Clinic in Peru 2020

Abstract

Background: Some studies have reported the association between hyperuricemia and atrial fibrillation (AF). However, there is little literature on this relationship in the setting of patients with type 2 diabetes mellitus (DM2). Objective: The present work aimed to evaluate the association between hyperuricemia and AF in patients with DM2. Methods: We carried out an analytical cross-sectional study where 386 medical records in adults diagnosed with DM2. We defined hyperuricemia as serum levels greater than 6 mg/dL in women and 7 mg/dL in men and the diagnosis of AF, using the report of the cardiologist and electrocardiogram. We use a generalized linear model of the Poisson family with robust variance and calculated crude and adjusted prevalence ratios (PR) with their 95% confidence interval (95% CI). Results: We observed hyperuricemia in 23.3% (n = 90) while 4.2% (n = 16) presented AF. We found a prevalence of hyperuricemia in 14.4% in patients with AF, while only 1% presented in those with normouricemia. In the multivariate analysis after adjusting the model with the significant variables such as hypertension, heart failure, use of allopurinol, direct bilirubin and use of ACE inhibitors, we found that patients with hyperuricemia; they are 9.66 times more likely to be associated with AF (PR= 9.66; 95%CI: 1.50-62.2). Conclusion: This study established a significant association between hyperuricemia and AF in DM2 patients. Further studies are needed to determine a causal relationship between both variables, as well as clinical trials, to investigate the therapeutic implications of this relationship.