Abstract
BackgroundHyperuricemia may be associated with an increased risk of coronary heart disease (CHD) mortality; however, the results from prospective studies are conflicting. The objective of this study was to assess the association between hyperuricemia and risk of CHD mortality by performing a meta-analysis.MethodsPubmed and Embase were searched for relevant prospective cohort studies published until July 2015. Studies were included only if they reported data on CHD mortality related to hyperuricemia in a general population. The pooled adjusted relative risk (RR) was calculated using a random-effects model.ResultsA total of 14 studies involving 341 389 adults were identified. Hyperuricemia was associated with an increased risk of CHD mortality (RR: 1.14; 95 % CI: 1.06–1.23) and all-cause mortality (RR: 1.20; 95 % CI: 1.13–1.28). For each increase of 1 mg/dl of serum uric acid (SUA), the overall risks of CHD and all-cause mortality increased by 20 and 9 %, respectively. According to the gender subgroup analyses, hyperuricemia increased the risk of CHD mortality in women (RR: 1.47; 95 % CI: 1.21–1.73) compared to men (RR: 1.10; 95 % CI: 1.00–1.19). The risk of all-cause mortality was greater in women.ConclusionsHyperuricemia may modestly increase the risk of CHD and all-cause mortality. Future research is needed to determine whether urate–lowering therapy has beneficial effects for reducing CHD mortality.Electronic supplementary materialThe online version of this article (doi:10.1186/s12872-016-0379-z) contains supplementary material, which is available to authorized users.
Highlights
Hyperuricemia may be associated with an increased risk of coronary heart disease (CHD) mortality; the results from prospective studies are conflicting
According to gender subgroup analyses, hyperuricemia increased the risk of CHD mortality in women (RR: 1.47; 95 % CI: 1.21–1.73) compared to men (RR: 1.10; 95 % CI: 1.00–1.19)
Hyperuricemia has been correlated with hypertension, hyperlipidemia, diabetes, metabolic syndrome and renal disease, all of which could contribute to increased CHD and all-cause mortality
Summary
Hyperuricemia may be associated with an increased risk of coronary heart disease (CHD) mortality; the results from prospective studies are conflicting. The objective of this study was to assess the association between hyperuricemia and risk of CHD mortality by performing a meta-analysis. Because of controversial epidemiologic findings and the lack of consistent evidence, Several observational studies [4, 8, 11, 12] demonstrated that elevated SUA has a predictive value for CHD risk and that hyperuricemia may be an important causal factor for CHD mortality. Known risk factors, such as age, gender, fat, weight index and other potential confounding factors, under- or over -estimate the association between hyperuricemia and the risk of related disease
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