HYPERTENSION AND COMORBIDITY AS MACE DEVELOPMENT RISK FACTORS IN THE EAST EUROPEAN REGION

Abstract

Objective: To identify the impact of Hypertension and comorbidity on the MACE development in the East European Region Design and method: In 2007/2008- 2012/2013 5-year prospective analysis was conducted. Evaluating cardiovascular risk factors with standard questionnaires, measurements of blood pressure, electrocardiography, blood chemistry (serum C-reactively protein, uric acid and cholesterol data) were included in the survey. In 5 years we registered new cases of MACE in the Belarusian population. Results: 70 new cases of MACE were developed in population of 3427 persons during 5-years survey. According to one-variable regression the MACE development was independently associated with the following risk factors adjusted for age and sex: COPD (p < 0.01), HF (p < 0.001), edema (p < 0.01), angina pectoris (p < 0.01), hypertension (p < 0.01), intermittent claudication (p < 0.05), low HDL-C level < 1.08 mmol/l, triglycerides level > 1.87 mmol/l (p < 0.05), myocardial infarction (p < 0.05), low physical activity (p < 0.1), family history of premature cardiovascular disease (p < 0.1). After including these parameters in multifactorial regression analysis and deriving the final model of MACE development (df = 1; x2 Walda = 32.2; p < 0.001) hypertension (p < 0.05), COPD (p < 0,01),HF (p < 0.01), low HDL-C level (<1.08 mmol / l) were significantly associatied with MACE development. Conclusions: Hypertension and comorbidity particularly dyslipidemia, COPD, HF are significant risk factors associated with MACE development in The East European Region.