Abstract
BackgroundThe full range of allergic reactions to Total Parenteral Nutrition (TPN) remains unknown. Additionally, beyond individual allergens, there may be other factors contributing to TPN hypersensitivity reactions.Case presentationWe present a case of a patient with negative skin testing to common TPN allergens who had recurrent urticarial reactions to TPN. Her skin reactions resolved once TPN was stopped. Following a literature review, we postulated that the reactions could be due to the high osmolality of her TPN. Consequently, lowering her TPN from 2785 to 1928 mOsm/kg and premedicating with cetirizine resulted in resolution of her urticaria.ConclusionsWhen looking at patients who have hypersensitivity reactions to TPN, one must consider that their reactions may be due to factors other than allergens. More studies are needed to clarify the relationship between high osmolality TPN infusions and non-IgE mediated hypersensitivity reactions.
Highlights
The full range of allergic reactions to Total Parenteral Nutrition (TPN) remains unknown
When looking at patients who have hypersensitivity reactions to TPN, one must consider that their reactions may be due to factors other than allergens
More studies are needed to clarify the relationship between high osmolality TPN infusions and non-IgE mediated hypersensitivity reactions
Summary
When looking at patients who have hypersensitivity reactions to TPN, one must consider that their reactions may be due to factors other than allergens.
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