Abstract

We examined subjects with exercise-induced asthma to assess the short-term reproducibility of hyperpolarized (Hp) helium-3 (<sup>3</sup>He) magnetic resonance imaging (MRI) of regional ventilation defects before asthma exacerbation. Our objective was to evaluate pre-exercise interscan Hp <sup>3</sup>He MRI measurement reproducibility of subjects scanned on three separate occasions (5 &plusmn; 2 days between sessions). Magnetic resonance imaging was performed at 3.0 Tesla with a custom-built rigid elliptical <sup>3</sup>He chest coil. Images for six subjects were evaluated by two observers; one who quantified ventilation defect score and ventilation defect volume and another who quantified percent ventilated volume. For all six subjects, pre-exercise ventilation defect location and number of defects were similar at all three visits suggesting persistence of many defects, but changes in defect volume and percent ventilated volume were detected.

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