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Abstract
RATIONALE: To date, no studies have quantitatively evaluated chronic obstructive pulmonary disease (COPD) longitudinally using hyperpolarized helium-3 () magnetic resonance imaging (MRI). OBJECTIVES: To evaluate COPD longitudinally using hyperpolarized MRI and to determine correlations between the changes in MRI ventilation defect volume (VDV), apparent diffusion coefficients (ADC) and changes in pulmonary function. METHODS: Hyperpolarized MRI, spirometry and plethysmography were performed in 15 COPD ex-smokers ( stage II and stage III/IV COPD) at baseline and 26±2 months later. MRI ADC values were calculated from MRI diffusion-weighted images and VDV were generated after manual segmentation of MRI spin-density images. MEASUREMENTS AND MAIN RESULTS: At follow-up, COPD subjects showed significant increases in MRI CS VDV (), WL VDV (), as well as ADC () and no significant change in (). There was a significant correlation between changes in and changes in CS VDV (, ), however no significant correlations between smoking history (years non-smoker at baseline) and changes in MRI measurements or was found. CONCLUSIONS: For COPD ex-smokers, MRI VDV and ADC measurements worsened significantly but there was no significant change in FEV1, suggesting higher sensitivity of hyperpolarized MRI to COPD changes over short periods of time.
Published Version
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