Abstract
Our previous retrospective cohort study found a significant increase of preeclampsia in pregnancies conceived through in vitro fertilization - embryo transfer (IVF-ET) compared to naturally conceived pregnancies (OR, 1.9, 95% CI 1.5-2.5). IVF-ET manipulates gametes and embryos during the pivotal stage of methylation reprogramming, so it is likely to induce inappropriate methylation and lead to preeclampsia. Considering syncytin 2 encoded by HERV-FRD plays a key role in trophoblast cell fusion and placenta invasion, deficiency of syncytin 2 might contribute in the development of preeclampsia.
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