Abstract
Serum-lipoprotein patterns were determined by "MNC analysis " (membrane filtration, nephelometry, and serum-cholesterol estimation) in 33 patients with nephrotic syndrome, some of whom were in spontaneous or steroid-induced remission. 17 of the patients had abnormal lipoprotein patterns, in 82% of which increased concentrations of both Sf 0-20 (β) and Sf 20-400 (pre-β) lipoproteins were found. This observation is contrasted with the much lower prevalence of this variety of hyperlipoproteinæmia (8.5% of abnormal patterns) previously reported in a randomly selected group from the same geographical area. Because of the association between hyperlipoproteinæmias and ischæmic heart-disease, it is advisable to examine the lipoprotein patterns of all subjects with nephrotic syndrome and to treat any significant abnormality. This course of action is now feasible with the simple and inexpensive form of lipoprotein analysis used in this study.
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