Abstract
The technique of membrane filtration and nephelometry together with a serum cholesterol estimation (MNC), has been used to estimate the concentrations of Sf 0–20, Sf 20–400 and Sf > 400 lipoproteins, which are here called small (S) medium (M) and large (L) particles. The distribution of S, M and L particles in 216 healthy young subjects is reported, and forms the basis for denning cut-off levels for each fraction. A number of different types of lipoprotein pattern are described using these criteria, and are shown to correspond to the types of pattern defined by other authors. The prevalence of these different types of hyperlipoproteinaemia in a randomly selected group of 747 subjects is reported. The classification of lipoprotein patterns by MNC is compared in 80 sera with the classification using analytical ultracentrifugation; good agreement is shown in the majority of sera. In order to simplify the recognition and reporting of the different types of hyperlipoproteinaemia, a form of lipoprotein profile (the SML profile) is described.
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