Hyperlipoproteinemia in rabbits induced by intravenous administration of fat emulsions and heparin

Abstract

Summary The data presented show that intravenous infusion of triglycerides into normal rabbits in the presence of heparin induces elevation in the concentration of plasma very low density lipoproteins. No exogenous free fatty acid mobilizing hormone was given. The effect is therefore referred to metabolic consequences of the fat infusion itself. The data are compatible with the possibility that rapid hepatic uptake of triglycerides, like uptake of free fatty acids, stimulates production and secretion of lipoproteins, but other possible mechanisms cannot be ruled out.