Abstract
BackgroundB-type natriuretic peptide (BNP), a member of the natriuretic peptide family, is a cardiac-derived secretory hormone with natriuretic, diuretic, and vasorelaxant activities. Intraabdominal fat accumulation is associated with atherosclerotic cardiovascular diseases and cardiac dysfunction. Circulating BNP levels are relatively low (within the normal limits) in obesity and the metabolic syndrome. However, the relationship between plasma BNP levels and visceral fat accumulation in general population has not been reported. The present study analyzed the relationships between plasma BNP levels and various clinical variables, including insulin, visceral and subcutaneous fat area (VFA and SFA, respectively), in normal Japanese men.MethodsThe study (Victor-J study) subjects were consecutive 500 Japanese male workers, who underwent a health checkup and were measured VFA and SFA by computed tomography.ResultsAge-adjusted simple linear regression analysis showed that log-BNP correlated positively with HDL-cholesterol, and negatively with VFA, log-immunoreactive insulin (IRI), log-triglyceride, and LDL-cholesterol, but not body mass index or SFA. Stepwise multiple regression analysis identified log-IRI and HDL-cholesterol as significant determinants of log-BNP. Subjects with IRI ≥5.5 μIU/mL had lower plasma BNP levels than those with IRI < 5.5 μIU/mL, irrespective of obesity (body mass index, cutoff value 25 kg/m2), visceral fat accumulation (VFA, cutoff value 100 cm2) and subcutaneous fat accumulation (SFA, cutoff value 128 cm2).ConclusionsOur study showed that hyperinsulinemia correlated with low levels of plasma BNP in general men, irrespective of fat distribution.Trial registrationUMIN 000004318.
Highlights
B-type natriuretic peptide (BNP), a member of the natriuretic peptide family, is a cardiac-derived secretory hormone with natriuretic, diuretic, and vasorelaxant activities
The present study analyzed the relationships between plasma BNP levels and various clinical variables, including insulin, visceral and subcutaneous fat area (VFA and Subcutaneous fat area (SFA), respectively), in normal Japanese men
Venous blood samples were collected in the morning after overnight fast for measurements of creatinine, hemoglobin A1c (HbA1c), HDL-cholesterol, LDLcholesterol, triglyceride, glucose, and immunoreactive insulin (IRI)
Summary
B-type natriuretic peptide (BNP), a member of the natriuretic peptide family, is a cardiac-derived secretory hormone with natriuretic, diuretic, and vasorelaxant activities. Circulating BNP levels are relatively low (within the normal limits) in obesity and the metabolic syndrome. The relationship between plasma BNP levels and visceral fat accumulation in general population has not been reported. Plasma BNP level correlates with the severity of heart failure, and is clinically used as a marker of cardiac dysfunction [3]. Visceral fat accumulation correlated closely with systolic blood pressure [4], and is related to the development of cardiac dysfunction [5]. Circulating NPs levels are relatively low (within the normal limits) in obesity [6,7,8,9,10,11]. The present study analyzed the relationships between plasma BNP levels and various clinical variables, including insulin, visceral and subcutaneous fat area (VFA and SFA, respectively), in normal Japanese men
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