Effect of B-type natriuretic peptide and D-dimer on the prognosis judgement of elderly patients with acute myocardial infarction

Abstract

Objective To evaluate the clinical application value of B-type natriuretic peptide and D-dimer on the prognosis judgement of elderly patients with acute myocardial infarction（ AMI ）. Methods One hundred and twenty-three AMI patients within six hours of onset were chose as observation group,and 46 physical examinees without coronary artery disease were chose as control group. The plasma BNP and D-dimer levels were detected by chemiluminescence and immunoturbidimetry,and the patients in observation group were followed up for 1 year,every 3 months one time. Results After AMI, the plasma BNP and D-dimer levels were significantly higher than those of the control group（ P﹤0. 01 ）. The BNP and D-dimer levels in plasma of AMI group,heart failure group and death group were significantly higher than those of the post-infarction angina group and recovery group（ P﹤0. 01 ）. The plasma BNP levels in patients with cardiovascular events during hospitalization and 1-year follow-up were significantly higher than those in patients without cardiovascular events（ P ﹤0. 01 ）. Cardiovascular events in patients with higher BNP levels were more（ P﹤0 . 05 ）. The plasma BNP levels were positively correlated with mortality（ r=0. 54 ,P﹤0. 01 ）. The plasma BNP and D-dimer levels of patients with AMI signifi-cantly decreased after early treatment（ P﹤0. 01 ）. Conclusions The plasma BNP and D-dimer levels of elderly patients with AMI increase obviously,and the elevated levels are closely correlated with the severity of the disease,so the plasma BNP and D-dimer levels have practical clinical value on the disease outcome and efficacy assessments of the elderly patients with AMI. Key words: Myocardial infarction in elderly; B-type natriuretic peptide; D-dimer; Prognosis; Assessment