Abstract
Hyperhemolysis syndrome (HHS) and hypersplenism (HS) are two distinct clinical entities that can present with similar manifestations, leading to diagnostic challenges. This article compares and contrasts these conditions, focusing on their pathophysiology, clinical presentation, laboratory findings, and management approaches. HHS, a life-threatening complication of packed red cell transfusion, involves the destruction of both allogenic and autologous red cells, often resulting in a sudden drop in hemoglobin levels post-transfusion. On the other hand, HS is characterized by splenomegaly and excessive sequestration and destruction of blood cells, including red blood cells, white blood cells, and platelets. Differentiating between these conditions is essential for accurate diagnosis and tailored treatment. Management of HHS typically involves intravenous immune globulin and steroids, while HS may require splenectomy or addressing the underlying cause of splenomegaly. Through case reports and clinical scenarios, this article provides insights into the diagnostic and therapeutic strategies for managing these conditions effectively.
Published Version
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