Abstract
THE presence of a hyperglycemic agent in extracts of urine from human subjects has been repeatedly reported (Houssay and Biasotti, 1933; Dingemanse and Kober, 1933; Mather, Katzman and Doisy, 1933–34; Harrow, Naiman, Chamelin and Mazur, 1934). Houssay et al. (1933) were able to demonstrate the presence of this activity more frequently in the urine of diabetic patients than in specimens from normal men. On the other hand Werch and Altschuler (1937) were not able to detect hyperglycemic activity in urine from normal individuals. Some of the early workers (Dingemanse et al., 1933; Mather et al., 1933), found this activity associated with gonadotrophic material, but purified gonadotrophins were later shown to be free of hyperglycemic activity (Davis, Hinsey and Markee, 1934). These latter authors suggested that the hyperglycemic effect of urinary preparations could be due to salts of uric or hippuric acids, which they demonstrated to be hypergfycemic when injected into rabbits.
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