Abstract
A simplified scheme for interpretation of urinary hippuric acid excretion data in terms of consecutive irreversible first-order processes is presented. The rate of excretion of endogenous hippuric, uric, and glucuronic acids is constant under the conditions of the experiments. The average value for the excretion constant KE for exogenous hippuric acid has been determined to be 2.7 hr-1 (0.0452 min-1) for doses of sodium hippurate ranging from 1 to 4 mEq. The average Ks for synthesis of hippurate from benzoate is 10.5 hr-1 (0.175 min-1) for doses of sodium benzoate ranging from 1 to 4 mEq. Study of 17 patients with varying degrees of renal disease as confirmed by standard p-aminohippurate and inulin clearances indicates that the determination of KE may be of value in the study of renal function, particularly where standard clearance techniques are not available. Preliminary data indicate that Ks may be useful in the study of the delay in synthesis of hippurate from benzoate that has been observed in some cases of liver pathology. Submitted on August 29, 1960
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