Abstract
Summary Glucoprivation effects on blood glucose (BG) and insulin (I) secretion have been investigated in rats bearing electrolytic lesions in the hypothalamic glucoreceptor areas. Systemic administration of 2-deoxy-D-glucose (2-DG) to rats bilaterally lesioned 24–48 hr before in the ventromedial (VMH) or/and ventrolateral (LHA) hypothalamus induced a BG rise and inhibition of rise in plasma I levels not dissimilar from those elicited in sham-operated rats. The threshold dose for 2-DG effects (60 mg/kg) was the same for VMH-LHA lesioned rats and sham-operated controls. These results suggest the existence of peripheral glucoreceptors for the hyperglycemic and insulin inhibiting effects of 2-DG but do not exclude the presence in the brain of other glucosensitive areas besides the VMH and LHA.
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