Abstract
The present study was carried out to examine the effect of the hepatic branch of the vagus nerve on the secretion of insulin and glucagon after intraperitoneal injection of L-arginine, L-alanine, and L-leucine in rats. Sectioning of the hepatic branch of the vagus nerve enhanced both plasma insulin and glucagon secretion compared to that in sham-operated (control) rats after intraperitoneal arginine. Sectioning of the hepatic branch of the vagus nerve enhanced plasma glucagon secretion after intraperitoneal alanine, and plasma insulin secretion after intraperitoneal leucine compared to that in sham-operated rats. The results suggest that the hepatic branch of the vagus nerve inhibits arginine-induced insulin and glucagon secretion, alanine-induced glucagon secretion, and leucine-induced insulin secretion. The existence of’sensors’ in the liver for arginine, alanine, and leucine is proposed as an explanation for the inhibition of the secretion of insulin and/or glucagon by the hepatic vagus nerve.
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