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Abstract
We report the results of hyperbaric oxygen therapy (HBO) for pancreatic and gastrointestinal disease. Thirty-nine patients received 100% oxygen at 2 atmospheres absolute pressure for 60 min. Results: In all four patients with liver abscess, feverishness subsided within 2.7 days after the start of HBO. All of three patients with infection after hepatic resection were relieved of systemic inflammatory response system (SIRS) and showed reduced CRP levels after HBO. In all of seven patients with acute appendicitis, pyrexia was relieved at 1.8 days after HBO introduction, and further surgery was not necessary. Among five patients with colorectal disease, HBO was effective in four, but ineffective in one. Five of six cases of infection after pancreatic resection were cured immediately after HBO. There were no complications such as middle ear inflammation, oxygen intoxication or pneumothorax. Conclusions: HBO is sometimes effective for treatment of refractory gastro enteric infections, especially those for which drainage is difficult. Pyrexia improved within 2.3 days after the start of HBO in most cases. If infection is refractory to standard antibiotics or drainage, HBO should be considered as an additional treatment. Since HBO is safe and generally cost-effective, it should be considered as an adjunct therapy for all gastro enteric infections.
Highlights
In the field of abdominal surgery, hyperbaric oxygen therapy (HBO) is used mainly for adhesive ileus [1] and peumatosis intestinalis [2,3]
HBO is sometimes effective for treatment of refractory gastro enteric infections, especially those for which drainage is difficult
Pyrexia improved within 2.3 days after the start of HBO in most cases
Summary
In the field of abdominal surgery, hyperbaric oxygen therapy (HBO) is used mainly for adhesive ileus [1] and peumatosis intestinalis [2,3]. Few reports have documented the use of HBO in other fields of gastroenterology. HBO has been shown to be especially effective for healing of complex ischemic wounds in patients with atherosclerosis or diabetes mellitus [4]. HBO has been used in cases of liver failure and liver transplantation [5]. HBO with 100% oxygen at twice sea level atmospheric pressure can create an arterial oxygen tension in excess of 2000 mmHg, and almost 400 mmHg in tissues [6]. We examined the utility of HBO for various gastroenteric diseases
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