Hygienic Chemical Studies on Poisonous Metal. II. Acute and Subacute Toxicity Tests of Cadmium Chloride

Abstract

Following the previous report on body retention, excretion, and distribution of cadmium chloride (115mCdCl2) after a single oral administration in rats acute and subacute toxicity tests were made on cadmium chloride and the results were as follows : LD50 of cadmium chloride by a single oral administration in female rats was 168.6 mg/kg body weight, and its confidence limit was 149.0-191.0 mg/kg. These rats in the acute toxicity tests of cadmium chloride reduced spontaneous movement, became hyposensitive to external stimulus, and then showed nasal discharge or nasal hemorrhage. Thereafter, these rats eventually died of respiratory embarrassment. The subacute toxicity was examined by continuous oral administration of 5 or 20 mg/kg/day of cadmium chloride for 30 days in male and female rats. Experimentally, male rats showed inhibition of the growth, but not the female rats. It was recognized that the volumes of daily urine increased for 30 days. After administration, weight of the liver decreased, but not that of the kidney. The weight of stomach, small intestine and large intestines increased markedly.