Abstract
Investigative research is the foundation of innovation that drives a first-world quality of life. Because we stand on the shoulders of scientific giants, we live longer, healthier and more productive lives than any humans in the history of civilization. The laboratory mouse is one tool that enables innovation to move forward, with 20-30 million mice used across the US each year. Many variables contribute to the environment surrounding the laboratory mouse in an individually ventilated cage (IVC), such as the type of cage used, the composition and volume of bedding used, the number of air changes per hour (ACH), the frequency of bedding changes, the frequency of cage changes and the temperature and relative humidity of air in the cage.
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