Abstract
We aimed to explore the expression characteristics of HSDL2 in osteosarcoma (OS) as well as the underlying mechanism. A total of 42 OS patients’ tissue samples were collected. HSDL2 level was markedly higher in OS tissues as well as OS cell lines. Besides, patients with high HSDL2 expression had a higher incidence of distant metastasis and a lower overall survival rate. Furthermore, the ability of OS cells to proliferate, invade and metastasize was markedly reduced after HSDL2 knockdown; however, the overexpression of HSDL2 could markedly increase the proliferative, invasive and metastasis ability of OS cells. In addition, HSDL2 can target FGFR4. Furthermore, FGFR4 expression was markedly decreased after HSDL2 knockdown, besides, HSDL2 and FGFR4 expressions were positively correlated in OS tissues. In addition, the recovery experiments suggested that HSDL2 and FGFR4 had a mutual regulation, thereby jointly promoting the invasive and migration ability of OS. HSDL2 expression was markedly increased in OS tissues as well as OS cell lines, which was markedly related to distant metastasis along with poor prognosis of OS patients. Besides, HSDL2 may promote OS progression by increasing the FGFR4 expression.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
