Abstract
The study aims to prepare a smart copolymeric for controlled delivery of Galantamine hydrobromide. The synthesis of the hydrogel was executed through free radical polymerization using HPMC (Hydroxypropyl methylcellulose) and pectin as polymers and acrylic acid as monomer. Cross-linking was performed by methylene bisacrylamide (MBA). HPMC-pectin-co-acrylic acid hydrogel was loaded with Galantamine hydrobromide (antidementia drug) as a model drug for treatment of Alzheimer based dementia. Formulated hydrogels (SN1–SN9) were characterized for Fourier transform-infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, X-ray diffraction, and energy dispersive X-ray. Drug loading efficiency, gel fraction, measurements of porosity, and tensile strength were reported. Swelling and release studies were performed at pH 1.2 and 7.4. Drug liberation mechanism was evaluated by applying different release kinetic models. Galantamine hydrobromide was released from prepared hydrogels by Fickian release mechanism. Swelling, gel fraction, porosity, and drug release percentages were found to be dependent on hydroxypropyl methylcellulose, pectin, acrylic acid, and methylene bisacrylamide concentrations. By increasing HPMC amount, swelling was increased from 76.7% to 95.9%. Toxicity studies were conducted on albino male rabbits for a period of 14 days. Hematological and histopathological studies were carried out to evaluate safety level of hydrogel. Successfully prepared HPMC-pectin-co-acrylic acid hydrogel showed good swelling and release kinetics, which may help greatly in providing controlled release drug effect leading to enhanced patient compliance for dementia patients.
Highlights
Innovative approaches and advancements in biomedical science help in providing improved drug delivery systems
methylene bisacrylamide (MBA) cross-linked Hydroxypropyl methylcellulose (HPMC)-pectin-co-acrylic acid hydrogels were fabricated by free radical polymerization for controlled delivery of Galantamine hydrobromide
Fourier Transform Infrared (FTIR) analysis of all ingredients, i.e., HPMC, pectin, acrylic acid, MBA, Galantamine hydrobromide, and fabricated hydrogels was performed for confirmation of the identity and compatibility of ingredients
Summary
Innovative approaches and advancements in biomedical science help in providing improved drug delivery systems. MBA cross-linked HPMC-pectin-co-acrylic acid hydrogels were fabricated by free radical polymerization for controlled delivery of Galantamine hydrobromide. Controlled release oral hydrogels of Galantamine hydrobromide can give a better and more efficient way of administrating the therapeutic amount of drug as a single dose, thereby reducing the frequency of dosing. Such a system shall maintain the steady state drug plasma levels, which would be beneficial for dementia patients as they are much more reluctant to take their medications and often forget to take their medicines because of their mental condition. The fabricated hydrogels were evaluated by different characterization tests, and their in vitro drug release profile was studied
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