Abstract
WHILE carrying out a study of hydroxyproline synthesis in biological media, by hydroxylation of proline or peptides containing proline, we have also investigated the possibility of hydroxylation of pyrrolidine ring in vitro. We commenced our study by ascertaining1,2,3 whether or not cortisone inhibited the formation of free hydroxyproline in animal tissues during their embryonal development and thus interfered with the biosynthesis of collagen.
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