Abstract
Abstract The biosynthesis of collagen was studied in synovial tissue specimens taken from 12 patients with rheumatoid arthritis and from 9 control subjects. The synovial samples, obtained at operation, were incubated in a medium containing radioactive proline, and the formation of nondialyzable radioactive hydroxyproline was taken as an index of the rate of collagen biosynthesis. Furthermore, total 14 C radioactivity incorporated into the nondialyzable fraction served as a parameter of the over-all synthesis of proteins. The formation of radioactive hydroxyproline in the nondialyzable fraction was increased in synovial specimens obtained from patients with rheumatoid arthritis, as compared to the controls. The incorporation of total 14 C radioactivity into nondialyzable fraction was not changed in rheumatoid samples. The concentration of free proline in synovial tissue was increased in rheumatoid arthritis, and a significant correlation between the free 12 C-proline concentration and 14 C-hydroxyproline formation could be observed in the synovial tissue specimens. The present results seem to suggest that the biosynthesis of collagen is increased in rheumatoid synovial tissue.
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