Hydroxyapatite integrated with cellulose acetate/polyetherimide composite membrane for biomedical applications

Abstract

AbstractIn this study, we describe the experience of a simple, cost‐efficient preparation and characterization of hydroxyapatite (HA) nanomaterial incorporated cellulose acetate/polyetherimide membrane for adsorption and biomedical applications. A simple chemical precipitation technique has been used for the synthesis of HA nanoparticles. The membrane was then developed by incorporating nanoparticles into different compositions of cellulose acetate and polyetherimide by using a phase inversion technique. Fourier transmission infrared spectroscopy, X‐ray diffraction spectroscopy, high‐resolution transmission electron microscope, field emission scanning electron microscope, and energy dispersive X‐ray spectroscopy were used to characterize the structural analysis and morphology of the nanoparticles and polymer membrane. Thermo gravimetric analysis was used to describe thermal characteristics. The contact angle value and wettability test were used to determine the hydrophilicity of the polymer membrane. The images from the scanning electron microscope analysis indicate that the addition of hydroxyapatite nanoparticles causes significant morphological changes in the membrane's surface and cross section. When compared with a control membrane, the presence of inorganic nanoparticles elucidated the impact on thermal and hydrophilic properties. The CA/PEI/HA membrane can be used as an adsorbent material in dye adsorption experiments with model dyes such as Malachite green, Methylene blue as cationic dyes, and Eriochrome black T, Congo red as anionic dyes. In addition, the biocompatibility of the CA/PEI/HA membrane was tested using cell cytotoxicity against THP‐1 human monocytic leukemia cells.