Hydrolysis of Double-Stranded and Single-Stranded RNA in Hairpin Structures by the Copper(II) Macrocycle Cu([9]aneN(3))Cl(2).

Abstract

A copper(II) macrocycle functions as an artificial ribonuclease. Cu([9]aneN3)Cl2 hydrolyzes both a 20-base RNA hairpin oligonucleotide and a 31-base sequence of TAR, an RNA sequence found in HIV. T...