Abstract
AbstractFour different poly(ether urethane) gels were prepared by polyaddition of saccharide derivatives (1, 2, 3α, or 3β) and poly(propylene glycol) with an L‐lysine‐derived diisocyanate, methyl (S)‐2,6‐diisocyanatohexanoate (4). Dibutyltin dilaurate and triisocyanate 5, that was also derived from L‐lysine, were used as a catalyst and a crosslinking agent, respectively. Hydrogels containing 1, 2 or 3α were hydrolyzed in phosphate buffers (pH 5.5, 7.0, 8.0) at 27°C, while the hydrolysis of the gel bearing 3β did not occur even after immersion for 3 months. Release of 5(6)‐carboxyfluorescein (CF) and magnesium 8‐anilino‐1‐naphthalenesulfonate (ANS) from the hydrogels was investigated in buffers of different pH. The release behavior was significantly controlled by the degree of hydrolysis of the gels. Both hydrolysis and the release behavior of these gels depended on the pH value.
Published Version
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