Abstract
In order to exhibit moderate cytotoxic activity toward the human tumor cell lines including A-549, SK-OV-3, HT-1080, K562 and S180, the cytotoxicity-directed fractionation of Me OH extract of Geranium wilfordii Maxim led to the isolation of three hydrolyzed tannins and a related compound, Gallic acid (I), 1, 2, 3, 4, 6-penta-O-galloyl-&beta-D-glucopyranose (ll), chebulagic acid (Ⅲ) and chebulinic acid (IV), as active principles. They were shown to exhibit moderate cytotoxicity against cultured human tumor cell lines including A549, SK-OV-3, HT-1080, K562 and S180 <em>in vitro</em>.
Highlights
Geranium wilfordii Maxim is native to China and is widely distributed in China
Geranium wilfordii Maxim has been reported to exhibit a variety of biologicalactivities including anticancer (Yang et al, 2010; Wang et al, 2004) ant mutagenic (Okuda et al, 1983) antibacterial (Serkedj, 1997) Anti-Oxidant, protecting liver and antHIV (Lei et al, 2008)
Test for the cytotoxicity in vitro: Human tumor cell lines used in this experiment were obtained from Shanghai Institutes for Biological Sciences (SIBS) which were used in SIBS as standard cell lines for the in vitro drug screening on antitumor activity
Summary
Geranium wilfordii Maxim is native to China and is widely distributed in China. In Traditional Chinese Medicine, Geranium wilfordii Maxim is one of the important folk medicines. Geranium wilfordii Maxim has been reported to exhibit a variety of biologicalactivities including anticancer (Yang et al, 2010; Wang et al, 2004) ant mutagenic (Okuda et al, 1983) antibacterial (Serkedj, 1997) Anti-Oxidant, protecting liver and antHIV (Lei et al, 2008). Several flavonoids, organic acids, tannins and phenolic compounds have been isolated from Geranium wilfordii Maxim (Lei et al, 2008; Du et al, 2003; Mavlyanov et al, 1997).
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