Abstract
A survey of hydrolases in insects and mammals was carried out to obtain leads for the preparation of new selective poisons. The hydrolysis of 7 amides, 6 esters and 1 nitrile have been studied in whole homogenates of 5 insect species and the mouse, and in liver homogenates of rat, mouse and rabbit. No amidase activity was found. The results with esters are in agreement with the observations on the metabolism of known selective organophosphates.
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