Abstract
Diabetic cardiomyopathy is an important complication of diabetes mellitus and the main cause of diabetes death. Diabetic cardiomyopathy is related with many factors, such as hyperglycemia, lipid accumulation, oxidative stress, myocarditis, and apoptosis. Hydrogen sulfide (H2S) is a newly discovered signal molecule, which plays an important role in many physiological and pathological processes. Recent studies have shown that H2S is involved in improving diabetic cardiomyopathy, but its mechanism has not been fully elucidated. This review summarizes the research on the roles and mechanisms of H2S in diabetic cardiomyopathy in recent years to provide the basis for in-depth research in the future.
Highlights
Diabetes has reached epidemic levels, and its prevalence has increased significantly in recent years
NLRP3 gene silencing improves high glucose (HG)-induced cell apoptosis and inflammation, and the Toll-like receptor 4 (TLR4)/NF-κB pathway mediates the activation of NLRP3 induced by HG in cardiac cells. These results indicate that H2S improves Diabetic cardiomyopathy (DCM) by inhibiting HG-induced cardiomyocyte inflammation and apoptosis by suppressing the
Mechanism studies show that H2S suppresses HG-induced oxidative stress by activating the nuclear factor erythroid 2–related factor 2(Nrf2)/antioxidant response element (ARE) pathway, decreases HG-induced apoptosis through inhibiting the c-Jun N-terminal kinase (JNK)/p38 MAPK pathways, and activating the phosphatidylinositol 3kinase (PI3K)/Akt pathway (Zhou et al, 2015)
Summary
Reviewed by: Valentina Citi, University of Pisa, Italy Lara Testai, University of Pisa, Italy Zhongjian Cheng, Temple University, United States. Specialty section: This article was submitted to Cellular Biochemistry, a section of the journal Frontiers in Cell and Developmental. Diabetic cardiomyopathy is an important complication of diabetes mellitus and the main cause of diabetes death. Diabetic cardiomyopathy is related with many factors, such as hyperglycemia, lipid accumulation, oxidative stress, myocarditis, and apoptosis. Hydrogen sulfide (H2S) is a newly discovered signal molecule, which plays an important role in many physiological and pathological processes. Recent studies have shown that H2S is involved in improving diabetic cardiomyopathy, but its mechanism has not been fully elucidated. This review summarizes the research on the roles and mechanisms of H2S in diabetic cardiomyopathy in recent years to provide the basis for in-depth research in the future
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