Abstract
Diabetic cardiomyopathy is one of the main causes of death in patients with type 2 diabetes mellitus, which is independent of hypertension and coronary heart disease. However, the pathogenesis of diabetic cardiomyopathy has not been fully elucidated yet. Endoplasmic reticulum and mitochondria are important intracellular organelles involved in cellular activities. The interactions between these two organelles are closely correlated with various cell signaling pathways. Recent studies have shown that high glucose can lose the interaction between endoplasmic reticulum and mitochondria. The change of the interactions between endoplasmic reticulum and mitochondria are involved in the development of diabetic cardiomyopathy by regulating endoplasmic reticulum stress, cellular hypoxia stress, and Ca2+ homeostasis. Key words: Diabetic cardiomyopathy; Mitochondria; Endoplasmic reticulum; Mitochondria-associated endoplasmic reticulum membranes
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