Hydrogen-bonding patterns in bis(trimethoprim) dipicolinate pentahydrate

Abstract

In the title compound, 2C14H19N4O3+·C7H3NO42−·5H2O, the asymmetric unit contains two trimethoprim cations (A and B), a dipicolinate anion and five water mol­ecules. One of the picolinate carboxyl­ate groups inter­acts with cation A via a pair of N—H⋯O hydrogen bonds, forming a ring motif R{_2^2}(8). A loop of O—H⋯O hydrogen bonds is formed between four water mol­ecules and the two carboxyl­ate groups to form a supramolecular chain along the a axis. Mol­ecules A and B constitute a base pair via N—H⋯N hydrogen bonds, and these base pairs are cross-linked by N—H⋯O and C—H⋯O hydrogen bonds.