Abstract
Three new crystal structures containing [PtCl6]2−, pyridinium and benzimidazole groups have been prepared: [PtCl6]·(H-bzm)2·2(H2O) (1), [PtCl6]·(H-bipy)2·2(H2O) (2), [PtCl6]·(H-dimethyl-bipy)2·2(H2O) (3) [H-bzm: benzimidazole cation, H-bipy: 2,2′-bipyridine cation, H-dimethyl-bipy: 4,4′-bimethyl-2,2′-bipyridine cation]. All compounds have been fully characterized by elemental analyses, single-crystal X-ray analyses, IR spectra, TG analyses, and fluorescence studies. Single-crystal X-ray diffraction analysis suggests that the primary synthon contains +N–H···Cl−, including ionic bonding and hydrogen bonding interactions. The dimensions are enhanced further by secondary O–H ∙∙Cl and N–H ∙∙O hydrogen bonding interactions between donor and acceptor atoms located at the periphery of these synthons. Moreover, coulombic attractions between the ions play an important role in reinforcing the structures of these complexes. In addition, antitumor activity against human lung adenocarcinoma cell line (A549) and human nasopharyngeal carcinoma cell line (CNE-2) was performed. These complexes all showed inhibition to the two cell lines, while complex 3 exhibited higher efficiency than complexes 1–2.
Highlights
Due to its wide range of applications in materials science, molecular recognition, the pharmaceutical chemistry, and so on [1,2,3], crystal engineering has attracted interest from chemists, medical researchers, and materials scientists in the past few decades
As [PtCl6 ]2− is negative and [H-bzm]+ is positive, the coulombic attractions between the two ions play an important role in building up the crystal structure [28]
From the above information on the three [PtCl6 ]2 − salt species, we discover that the primary hydrogen-bonding supramolecular synthons, such as N–H . . . O, O–H . . . Cl and
Summary
Due to its wide range of applications in materials science, molecular recognition, the pharmaceutical chemistry, and so on [1,2,3], crystal engineering has attracted interest from chemists, medical researchers, and materials scientists in the past few decades. Angular pyridinium cations and their derivatives have been successfully employed to construct a series of molecular cocrystals with a variety of organic synthons or metal complexes such as perhalometalates [10,11,12], since the cations are the hydrogen-bond donors, linking the anionic ions that act as hydrogen-bond acceptors through coordinative bonds and/or N–H ··Cl–M interactions to enhance structural diversity [13,14]. A series of crystal structures containing pyridinium cations and potassium tetrachloroplatinate have been cocrystallized with the hydrogen bond donor groups (N–H). The protonated bipyridine (Hbipy)+ and benzimidazole (Hbzm)+ were chosen to enrich hydrogen-bonded crystalline systems, giving rise to different molecular conformation and further crystal packing modes. O hydrogen-bonding interactions, with coulombic attractions between the cations and anions, building up supramolecular structures.
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