Abstract
AbstractThe design of bioactive scaffolding materials with favorable properties is paramount for successful application in biomedical engineering. Polymeric hydrogels attract significant attention as leading candidates for scaffold engineering due to their specific compositional and structural similarities to the natural extracellular matrix. The ability to control porosity, surface morphology, and size of hydrogel scaffolds has created new approaches to overcome various issues in tissue engineering such as vascularization, tissue architecture, and simultaneous multiple cells seeding. This review imparts an overview of hydrogel scaffolds based on synthetic and natural polymeric components (alginate, gelatin, and 2-hydroxyethyl methacrylate). We made hydrogel scaffolds with unique properties. Their in vitro and in vivo biological response, morphology, mechanical properties, porosity, hydrophilicity, and degradability were tested to find optimal patterns of tissue regeneration.KeywordsHydrogel scaffoldsAlginateGelatin2-Hydroxyethyl methacrylateTissue regeneration
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