Abstract
Hydrogels (HGs), as three-dimensional structures, are widely used in modern medicine, including regenerative medicine. The use of HGs in wound treatment and tissue engineering is a rapidly developing sector of medicine. The unique properties of HGs allow researchers to easily modify them to maximize their potential. Herein, we describe the physicochemical properties of HGs, which determine their subsequent applications in regenerative medicine and tissue engineering. Examples of chemical modifications of HGs and their applications are described based on the latest scientific reports.
Highlights
IntroductionHydrogels (HGs) are three-dimensional (3D) structures of relatively uncomplicated design
Hydrogels (HGs) are three-dimensional (3D) structures of relatively uncomplicated design.They are mainly composed of long chains of polymers, forming a complex matrix in which the spaces between polymeric chains are filled with water molecules
Scientists have shown that increasing the pH value resulted in a decrease in the swelling ratio of HG, and a lower pH forced the release of a larger amount of active anticancer substance, which influenced the effectiveness of the therapy
Summary
Hydrogels (HGs) are three-dimensional (3D) structures of relatively uncomplicated design They are mainly composed of long chains of polymers, forming a complex matrix in which the spaces between polymeric chains are filled with water molecules. A broader concept that includes tissue engineering is regenerative medicine, whose objective is to stimulate self-regenerative mechanisms of the human body. This process can be implemented using stem cells or growth factors. If the organism is not capable of regenerating itself, regenerative medicine exploits the benefits of tissue engineering This approach enables the transplantation of tissues or entire organs that have been grown in laboratory conditions (e.g., from cells obtained from a patient), so the rejection risk is minimized
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