Abstract
The contraction–expansion array (CEA) channel device utilizes hydrodynamic effects, which include inertial lift forces and Dean drag forces, to manipulate particles at a very high throughput and without external forces. The equilibrium position for the particles in a CEA channel can be affected by both the particle size and the flow streamlines. Here, four focusing patterns with different particle sizes were investigated, and the force mechanism was analyzed. We present four CEA channels with different aspect ratios ( $$\varphi$$ ) and expansion and contraction angles ( $${\alpha _{\text{e}}}$$ and $${\alpha _{\text{c}}}$$ ) based on the process of changing the particle equilibrium positions. The results show that 20 µm particles migrated to the side of the channel as the aspect ratio $$(\varphi )$$ increased, and the smaller expansion and contraction angles were conducive to the particle focusing. The Circle channel possesses the best focusing effect. Finally, the microfluidic system was applied for the separation of plasma, RBCs and NCI-H1299 cancer cells from blood with high efficiency and purity.
Published Version
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