HYDRAZONES AND FORMAZANS - INVESTIGATION AND TECHNOLOGY

Abstract

Viral infections are a constant human health problem. The growing danger of viral infections necessitates the search for new antiviral drugs that are not toxic to humans. Creating safe and effective antiviral drugs is difficult because viruses use host cells for replication. Moreover, main difficulty in developing vaccines and antiviral drugs is related to virus variation. One of the trends in the synthesis of new derivatives of existing antiviral drugs is focused on creating a new, more effective drug. This paper is devoted to the synthesis and research of hydrazones and formazans – potential antiviral drugs. Viral infections are a permanent problem of human health. Growing danger of viral infections gives rise to the need to find new antiviral drugs that are not toxic to humans. Creating safe and effective antiviral drugs is complicated as viruses use host cells for replication. Moreover, the basic complexity of vaccines and antiviral drugs development is associated with the virus variation. One of the trends in synthesis of new derivatives of existing viricides is focused on the creation of a new, more effective drug. Influence of electronic nature and location of substituents in aldehyde part of formazan molecule on their biological activity was studied. Influence of these factors on the reaction conditions during of hydrazones obtaining (temperature, pH, reaction time) was investigated. Based on these data, methods for preparing hydrazones and formazans have been improved. Using the PASS (Prediction of Activity Spectra for Substances) program, it was made a calculation of biological activity synthesized formazans, which showed that these compounds are effective against a number of cultures (P.aerugenosa, E.coli, S.aureus, B.subtilis, C.albicans). Possibility of using synthesized formazans as biologically active substances, which by their characteristics are not inferior to foreign analogues, has been proved. Principle circuits and manufacturing schemes have been developed for hydrazones and formazans obtaining with their possible introduction into industrial production. Research results showed the promise of finding new products in this series of compounds for further recommendation of the most effective derivative in medical research.